摘要

        抗生素耐药基因（ARGs）的环境行为和迁移模式引起了广泛的研究兴趣。然而，关于相应和非相应污染物对近岸环境中ARGs命运影响的研究却很少。本研究以莱州湾为研究对象，在相应污染物和非相应污染物的背景下，分析了莱州湾水体和沉积物中intI1、sul1、sul2、qnrS和aac（6’）-Ib的分布。intI1、sul1和sul2基因的丰度从内河口向沿海呈明显的下降趋势。sul1/sul2与沉积物中磺胺类抗生素残留量、intI1和sul1/sul2的丰度之间存在强正相关。统计分析表明，非相应污染物与ARG丰度存在部分相关性。这些结果表明，非相应污染物可能对莱州湾ARGs和intI1的丰度产生直接或间接的影响。

         The environmental behaviors and migration patterns of antibiotic resistance genes (ARGs) have attracted considerable research interest. However, there has been little research concerning the effects of corresponding and non-corresponding contaminants on the fate of ARGs in coastal environments. In the present study, the distribution of intI1, sul1, sul2, qnrS and aac(6')-Ib were analyzed in water and sediment samples of Laizhou Bay in the context of corresponding and non-corresponding contaminants. The abundance of intI1, sul1 and sul2 genes exhibited a clear decreasing trend extending from the inner estuary to the coastal area. Strong and positive correlations existed between sul1/sul2 and sulfonamide antibiotic residues in sediments, and between the abundances of intI1 and sul1/sul2. Statistical analyses indicated that non-corresponding contaminants were partially correlated with ARG abundances. These results suggest that non-corresponding contaminants may have direct or indirect influences on the abundances of ARGs and intI1 in the Laizhou Bay.

       https://linkinghub.elsevier.com/retrieve/pii/S0025-326X(18)30062-6