摘要

        抗生素耐药性是一个日益严重的全球性问题，抗生素耐药基因（ARGs）的环境行为和迁移模式引起了人们的广泛关注。了解ARG污染的远距离迁移至关重要。在本研究中，我们描述了ARG释放到水环境后的动态变化，并证明了传统化学污染物在ARGs传播机制中的重要性。我们假设ARG增殖的主要途径是从主动传输到被动传输。这种以抗生素为主的开关受到非相应污染物的驱动和影响。从内陆水环境到海洋环境，人类活动的影响逐渐减弱，而环境条件变化的影响则沿着这一梯度增强。本文的研究将有助于进一步了解ARG污染在各种水生环境中的分布和迁移，为揭示相应污染物和非相应污染物在抗生素耐药增殖过程中的作用提供一个现代的视角。

         Antibiotic resistance is a worsening global concern, and the environmental behaviors and migration patterns of antibiotic resistance genes (ARGs) have attracted considerable interest. Understanding the long-range transport of ARG pollution is crucial. In this study, we characterized the dynamics of ARG changes after their release into aquatic environments and demonstrated the importance of traditional chemical contaminants in the transmission mechanisms of ARGs. We hypothesized that the main route of ARG proliferation switches from active transmission to passive transmission. This antibiotic-dominated switch is motivated and affected by non-corresponding contaminants. The effect of anthropogenic activities gradually weakens from inland aquatic environments to ocean environments; however, the effect of changes in environmental conditions is enhanced along this gradient. The insights discussed in this study will help to improve the understanding of the distribution and migration of ARG pollution in various aquatic environments, and provide a modern perspective to reveal the effect of corresponding contaminants and non-corresponding contaminants in the process of antibiotic resistance proliferation.

        https://www.sciencedirect.com/science/article/pii/S0269749116328949?via%3Dihub