摘要

      皮肤是人体与外界环境的主要界面。为了了解微生物群落在城市轨道交通中如何变化并影响皮肤微生物群，我们在与香港轨道交通（MTR）系统中的扶手接触后对人掌微生物群进行了仿形。日内采样时间被确定为群落组成变化和复发的主要决定因素，而人类相关物种和临床重要的抗生素耐药基因（ARGs）被捕获作为p.m.信号。线特异性特征与线特异性环境暴露和城市特征显著相关。在大多数分析中，唯一的跨境线显示为异常值，并且显示出较高的相对丰度和临床重要ARG的显著日内增加（24.1%），表明潜在的跨境ARG传播，特别是四环素和万古霉素耐药。我们的研究为未来的公共卫生战略提供了重要的参考，以减轻城市和跨境病原体和精氨酸的传播。

       The skin functions as the primary interface between the human body and the external environment. To understand how the microbiome varies within urban mass transit and influences the skin microbiota, we profiled the human palm microbiome after contact with handrails within the Hong Kong Mass Transit Railway (MTR) system. Intraday sampling time was identified as the primary determinant of the variation and recurrence of the community composition, whereas human-associated species and clinically important antibiotic resistance genes (ARGs) were captured as p.m. signatures. Line-specific signatures were notably correlated with line-specific environmental exposures and city characteristics. The sole cross-border line appeared as an outlier in most analyses and showed high relative abundance and a significant intraday increment of clinically important ARGs (24.1%), suggesting potential cross-border ARG transmission, especially for tetracycline and vancomycin resistance. Our study provides an important reference for future public health strategies to mitigate intracity and cross-border pathogen and ARG transmission.

        https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31051-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124718310519%3Fshowall%3Dtrue