摘要

在世界范围内，大量兽医用抗生素被施用于家畜，并通过粪肥施肥到达农田，它们可能导致抗生素抗性决定因素的丰度和传播性增加。本文综述了近年来国内外畜禽粪便对土壤中兽药和耐药菌的研究进展、局限性和研究需求，以及畜禽粪便对土壤微生物群落结构和功能的影响。抗生素耐药基因( ARGs)的增多和传播可导致多种耐药的人类病原体的出现，这些病原体使抗生素越来越难以治疗细菌的感染。

Large amounts of veterinary antibiotics are applied worldwide to farm animals and reach agricultural fields by manure fertilization, where they might lead to an increased abundance and transferability of antibiotic-resistance determinants. In this review we discuss recent advances, limitations, and research needs in determining the fate of veterinary antibiotics and resistant bacteria applied with manure to soil, and their effects on the structure and function of soil microbial communities in bulk soils and the rhizosphere. The increased abundance and mobilization of antibiotic-resistance genes (ARGs) might contribute to the emergence of multi-resistant human pathogens that increasingly threaten the successful antibiotic treatment of bacterial infections.

http://www.sciencedirect.com/science/article/pii/S0966842X14001140