摘要
      本研究旨在分析表层沉积物中最常见污染物的水平和总毒性，并评估其对亚速海抗生素耐药性基因（ARGs）发生的影响。使用全细胞细菌lux生物传感器进行的生物测试显示，表面沉积物具有高度的整体毒性，并且存在导致氧化应激和蛋白质损伤的遗传毒性物质和物质。通过聚类分析表明，亚速海污染物的分布取决于表层沉积物的类型。显示了表层沉积物中14种ARGs的相对丰度和分布。主成分分析结果表明，非对应污染物不会对亚速海表层沉积物中ARGs的丰度产生直接影响。因此，需要研究非相应污染物在水生环境中ARGs的选择和分布中的重要性仍然是一个紧迫的问题。
Abstract
The present study aims to analyze the level and total toxicity of the most common pollutants in surface sediments and assess their impact on the occurrence of antibiotic resistance genes (ARGs) in the Sea of Azov. Biotesting using the whole-cell bacterial lux-biosensors showed high integral toxicity of surface sediments and the presence of genotoxicants and substances that cause oxidative stress and protein damage. Using cluster analysis, it was shown that the distribution of pollutants in the Sea of Azov depends on the type of surface sediments. The relative abundance and distribution of 14 ARGs in surface sediments were shown. Principle component analyses results suggest that non-corresponding contaminants do not exert direct influence on the ARGs abundance in the surface sediments of the Sea of Azov. Thus, the need to investigate the significance of non-corresponding pollutants in the selection and distribution of ARGs in the aquatic environment remains a pressing problem.

https://www.sciencedirect.com/science/article/abs/pii/S0025326X22008785