摘要

      携带抗生素耐药性基因的耐多药细菌引起的感染对全球公共卫生和人类健康构成严重威胁。在临床实践中，已经发现人类肠道微生物群是抗生素耐药性基因（ARGs）的“蓄水池”，因为肠道微生物群含有多种ARGs，并且肠道微生物组的结构受到存在的耐药性基因的影响。此外，ARGs可以以多种方式在肠道微生物组的物种内部和物种之间传播。为了更好地了解肠道微生物群ARGs及其对慢性病患者的影响，本文综述了ARGs的产生、传播ARGs常见载体、常见慢性病中肠道微生物群的特征、它们对预后的影响、ARGs治疗的现状以及未来研究应解决的问题。

Infections caused by multidrug-resistant bacteria carrying antibiotic resistance genes pose a severe threat to global public health and human health. In clinical practice, it has been found that human gut microbiota act as a “reservoir” of antibiotic resistance genes (ARGs) since gut microbiota contain a wide variety of ARGs, and that the structure of the gut microbiome is influenced by the profile of the drug resistance genes present. In addition, ARGs can spread within and between species of the gut microbiome in multiple ways. To better understand gut microbiota ARGs and their effects on patients with chronic diseases, this article reviews the generation of ARGs, common vectors that transmit ARGs, the characteristics of gut microbiota ARGs in common chronic diseases, their impact on prognosis, the current state of treatment for ARGs, and what should be addressed in future research.

https://www.frontiersin.org/articles/10.3389/fmicb.2022.1037389/full?id_mc=316646914