摘要
      近年来，地下水中抗生素和抗生素耐药基因（ARGs）的流行引起了人们的关注，因为它们具有潜在的公共健康风险。抗生素耐药性，包括ARGs和抗生素耐药性细菌（ARB），可以通过多种途径转移到城市含水层，如医院、水产养殖场、畜牧场、生活污水、污水处理厂和垃圾渗滤液的排放。目前的综述探讨了全球地下水资源中常见抗生素和相关耐药基因的发生和来源的综合信息，主要分布在城市地区。此外，抗生素的生产、地下水的出现和相关的ARGs之间的关系被强调为四环素类抗生素的案例研究。此外，还阐明了ARGs的转移和传播机制以及抗生素耐药性发展对健康的潜在影响。此外，还谈到了城市含水层中抗生素和ARGs的现有研究差距和进一步研究领域的前景。
Abstract
The prevalence of antibiotics and antibiotic resistant genes (ARGs) in groundwater has piqued attention in recent years, owing to their potential public health risks. Antibiotic resistome, including ARGs and antibiotic resistance bacteria (ARB), can be transferred to urban aquifers through several pathways such as discharges from hospitals, aquaculture farms, livestock farms, domestic sewerage, wastewater treatment plants, and landfill leachate. The current review explores comprehensive information about the occurrence and sources of frequently reported antibiotics and related resistance genes in global groundwater resources, mainly located in urban areas. Besides, nexus among antibiotics’ production, groundwater occurrence, and associated ARGs is highlighted as a case study for tetracycline antibiotics. Further, the transfer and dissemination mechanisms of ARGs and potential health impacts of antibiotic resistance development are also elucidated. Furthermore, existing research gaps and prospects for further areas of research on antibiotics and ARGs in urban aquifers are also addressed.

https://www.sciencedirect.com/science/article/abs/pii/S2468584421000969