摘要

抗生素和金属抵抗是一种全球性的现象和普遍的威胁。像天然水体一样将抗生素和金属释放到环境中会刺激抗性微生物，这些微生物可能成为其他致病菌耐药基因库的储库。该研究的目的是确定微生物多样性，五种河流中抗生素和金属抗性细菌的分布。对10种抗生素和5种金属测试了168克革兰氏阴性菌株的耐药性。该研究揭示了对氨苄青霉素（44.7％），链霉素（37.3％）和氯霉素（33.9％）耐药的细菌分离株的高发生率。在Ravi河中发现了最高水平的抗生素耐药性。五种河流的多重抗生素抗性（MAR）指数介于<0.2至0.6之间。显示对不同浓度重金属的耐受性。来自Rivers Ravi和Soan的样品中的高抗生素和金属抗性提示了细菌群体之间的共同抗性。

Antibiotic and metal resistance is a global occurring phenomenon and a universal threat. The release of antibiotics and metals into the environment like natural water bodies stimulates resistant microbes that could become a reservoir for a resistant gene pool for other pathogenic bacteria. The aim of the study was to determine microbial diversity, distribution of antibiotic and metal resistance bacteria from five rivers. The resistance of 168 Gram negative isolates was tested against 10 antibiotics and five metals. The study revealed a high incidence of bacterial isolates resistant to ampicillin (44.7%), streptomycin (37.3%) and chloramphenicol (33.9%). The highest level of antibiotic resistance was detected in the River Ravi. The multiple antibiotic resistance (MAR) index of the five rivers ranged from <0.2 to 0.6. Isolates displayed tolerance to different concentrations of heavy metals. High antibiotic and metal‐resistances in samples from the Rivers Ravi and Soan suggest co‐resistance amongst the bacterial populations.

https://onlinelibrary.wiley.com/doi/abs/10.1111/wej.12290