摘要
      胰腺癌（PAAD）是一种常见的、高度恶性和侵袭性的胃肠道肿瘤。PAAD的常规治疗效果不佳，患者预后不佳。蛋白质的合成和降解对肿瘤的发生和发展至关重要。聚集性自噬是一种选择性降解聚集蛋白的自噬。它通过降解蛋白质来减少聚集体的形成，从而减少对细胞的伤害。通过分解蛋白质，它减少了聚集体的形成；从而使对细胞的损伤最小化。为了评估PAAD患者对免疫疗法的反应和预后，在本研究中，我们开发了一种基于聚集蛋白聚集相关基因（ARGs）的可靠信号。我们获得了298个AGGLncRNA。基于单向Cox和LASSO分析的结果，构建了lncRNA签名。在风险模型中，低风险组患者的预后明显好于高风险组患者。此外，ROC曲线和列线图验证了风险模型预测PAAD预后的能力。低风险组和高危组的患者在功能富集和免疫分析方面表现出相当大的差异。关于药物敏感性，低风险组和高风险组具有不同的半数最大抑制浓度（IC50）。
Abstract
Pancreatic adenocarcinoma (PAAD) is a common, highly malignant, and aggressive gastrointestinal tumor. The conventional treatment of PAAD shows poor results, and patients have poor prognosis. The synthesis and degradation of proteins are essential for the occurrence and development of tumors. Aggrephagy is a type of autophagy that selectively degrades aggregated proteins. It decreases the formation of aggregates by degrading proteins, thus reducing the harm to cells. By breaking down proteins, it decreases the formation of aggregates; thus, minimizing damage to cells. For evaluating the response to immunotherapy and prognosis in PAAD patients, in this study, we developed a reliable signature based on aggrephagy-related genes (ARGs). We obtained 298 AGGLncRNAs. Based on the results of one-way Cox and LASSO analyses, the lncRNA signature was constructed. In the risk model, the prognosis of patients in the low-risk group was noticeably better than that of the patients in the high-risk group. Additionally, the ROC curves and nomograms validated the capacity of the risk model to predict the prognosis of PAAD. The patients in the low-risk and high-risk groups showed considerable variations in functional enrichment and immunological analysis. Regarding drug sensitivity, the low-risk and high-risk groups had different half-maximal inhibitory concentrations (IC50).

https://www.mdpi.com/2073-4425/14/1/124