摘要
      重金属污染会提高抗生素耐药性，对生态系统和公众健康造成担忧。在这里，我们研究了四种不同河流环境中的重金属浓度、重金属抗性细菌和抗生素抗性细菌及其相应的抗性基因和整合子，即低重金属和低废水、高重金属和低污水、低重金属和高污水以及高重金属和高废水水平。重金属与重金属耐药性、抗生素耐药性和整合子呈正相关（r＞0.60，p＜0.05），表明重金属选择性压力可导致重金属和抗生素耐药性同时通过整合子传播，这可能导致在重金属污染的环境中产生多重抗性细菌。此外，重金属耐药性和抗生素耐药性之间存在显著关联（r>0.60，p<0.05），表明重金属和抗生素耐药性通过相同或相关的机制联系在一起。发现1类整合子与重金属、重金属耐药性和抗生素耐药性具有很强的相关性（r＞0.60，p＜0.05），表明在重金属污染环境中抗生素耐药性共同选择的发生率较高。
Abstract
Heavy metal pollution can enhance the level of antibiotic resistance, posing concerns to ecosystem and public health. Here, we investigated heavy metal concentrations, heavy metal resistant bacteria and antibiotic resistant bacteria and their corresponding resistant genes, and integrons in four different river environments, i.e., low heavy metals and low wastewater, high heavy metals and low wastewater, low heavy metals and high wastewater, and high heavy metals and high wastewater levels. Heavy metals were found to show positive and significant correlations with heavy metal resistance and antibiotic resistance and integrons (r > 0.60, p < 0.05), indicating that heavy metal selective pressure can cause heavy metal and antibiotic resistance to be transmitted simultaneously via integrons, which can result in the development of multi-resistant bacteria in the heavy metal-polluted environments. Moreover, there were significant associations between heavy metal resistance and antibiotic resistance (r > 0.60, p < 0.05), demonstrating heavy metal and antibiotic resistance are connected via a same or related mechanism. Class 1 integrons were found to have strong correlations with heavy metals and heavy metal resistance and antibiotic resistance (r > 0.60, p < 0.05), indicating a higher occurrence of antibiotic resistance co-selection in the heavy metal-polluted environments.

https://www.sciencedirect.com/science/article/abs/pii/S0048969722061587