摘要
      目的：鉴定一名腹泻患者的广泛耐药铜绿假单胞菌。材料与方法：采用纸片扩散法检测抗菌药物敏感性。对铜绿假单胞菌基因组进行测序，以确定毒力、抗生素耐药性和原噬菌体编码基因。结果：P。铜绿假单胞菌对抗生素有广泛的耐药性。铜绿假单胞菌的基因组分析揭示了76个与抗微生物耐药性、外源性降解和三型分泌系统相关的基因。结论：这是首次报道与铜绿假单胞菌相关的腹泻。由于没有发现其他生物体，作者认为患者因接触抗生素而出现微生态失调，导致抗生素相关性腹泻。病原体表达的体内毒性可能与T3SS有关。
Abstract
Aim: To characterize extensively drug-resistant Pseudomonas aeruginosa from a patient with diarrhea. Materials & methods: Antimicrobial susceptibility was tested by the disk diffusion method. The P. aeruginosa genome was sequenced to identify virulence, antibiotic resistance and prophages encoding genes. Results:P. aeruginosa had a wide spectrum of resistance to antibiotics. Genomic analysis of P. aeruginosa revealed 76 genes associated with antimicrobial resistance, xenobiotic degradation and the type three secretion system. Conclusion: This is the first report on diarrhea associated with P. aeruginosa. Since no other organism was identified, the authors assume that the patient had dysbiosis due to antibiotic exposure, leading to antibiotic-associated diarrhea. The in vivo toxicity expressed by the pathogen may be associated with T3SS.

https://www.futuremedicine.com/doi/abs/10.2217/fmb-2022-0140