摘要

病原体中铁载体生物合成途径的比较研究为抗生素和宿主药物递送提供了潜在的靶标，作为计算上可行的微生物疗法的一部分。使用铁载体模型进行铁获取是所有微生物和微生物感染中已知对植物和动物造成严重破坏的基本且已建立的模型。细菌以及真菌病原体对抗生素耐药性的快速发展使我们处于一个必须摆脱使用单一或多种抗生素/化学抑制剂或药物阻断病原体的传统方式的边缘。 '特洛伊木马'策略是对这种迫切需求的回应，其中抗生素通过细胞和外膜上的铁载体受体远远潜入致病细胞。这种抗生素一旦进入，通过铁缺乏在机会病原体内产生“黑洞”情景。对于其铁载体由于它们的复杂构象和刚性价键而与走私药物不相容的病原体，还有另一种方法。借助铁载体生物合成途径，可实现抑制病原菌中这些铁载体的潜在靶标，从而控制致病性毒力。设计人造外源性铁载体的方法可用于竞争并成功吸收战斗力的病原体也包含在本评论中。这些受操纵的铁载体将像任何其他铁载体一样进入致病细胞，但不会分散铁，因为铁不足并因此控制病原体。这次审查的目的是提供策略来克服使用铁载体的微生物感染/病原体。

Comparative study of siderophore biosynthesis pathway in pathogens provides potential targets for antibiotics and host drug delivery as a part of computationally feasible microbial therapy. Iron acquisition using siderophore models is an essential and well established model in all microorganisms and microbial infections a known to cause great havoc to both plant and animal. Rapid development of antibiotic resistance in bacterial as well as fungal pathogens has drawn us at a verge where one has to get rid of the traditional way of obstructing pathogen using single or multiple antibiotic/chemical inhibitors or drugs. ‘Trojan horse’ strategy is an answer to this imperative call where antibiotic are by far sneaked into the pathogenic cell via the siderophore receptors at cell and outer membrane. This antibiotic once gets inside, generates a ‘black hole’ scenario within the opportunistic pathogens via iron scarcity. For pathogens whose siderophore are not compatible to smuggle drug due to their complex conformation and stiff valence bonds, there is another approach. By means of the siderophore biosynthesis pathways, potential targets for inhibition of these siderophores in pathogenic bacteria could be achieved and thus control pathogenic virulence. Method to design artificial exogenous siderophores for pathogens that would compete and succeed the battle of intake is also covered with this review. These manipulated siderophore would enter pathogenic cell like any other siderophore but will not disperse iron due to which iron inadequacy and hence pathogens control be accomplished. The aim of this review is to offer strategies to overcome the microbial infections/pathogens using siderophore.

https://www.sciencedirect.com/science/article/pii/S0168365917309458