摘要

抗微生物药物耐药性是人类和兽医领域迫切的全球健康挑战。 野生动物不直接接触临床相关抗生素; 然而，全球范围内已经越来越多地报道野生动物的抗菌抗性与人类和兽医药物的情况平行。 这是野生动物细菌耐药性的复杂性以及人，家畜，环境和野生动物之间可能的种间传播的基础。 本综述总结了目前在野生菌来源的肠杆菌科分离株中扩增的β-内酰胺酶（ESBL），AmpCβ-内酰胺酶，碳青霉烯酶和粘菌素耐药基因的数据。 这次审查的目的是更好地了解野生动物作为储层和载体在全球传播关键的临床抗菌药物耐药性中的重要作用。 在这方面，世界各地迫切需要继续进行监督。

Antimicrobial resistance is an urgent global health challenge in human and veterinary medicine. Wild animals are not directly exposed to clinically relevant antibiotics; however, antibacterial resistance in wild animals has been increasingly reported worldwide in parallel to the situation in human and veterinary medicine. This underlies the complexity of bacterial resistance in wild animals and the possible interspecies transmission between humans, domestic animals, the environment, and wildlife. This review summarizes the current data on expanded-spectrum β-lactamase (ESBL), AmpC β-lactamase, carbapenemase, and colistin resistance genes in Enterobacteriaceae isolates of wildlife origin. The aim of this review is to better understand the important role of wild animals as reservoirs and vectors in the global dissemination of crucial clinical antibacterial resistance. In this regard, continued surveillance is urgently needed worldwide.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396029/