目的：
整合子在抗生素耐药性转移中的作用是重要问题之一，因此，本研究旨在研究抗生素耐药模式和分离的铜绿假单胞菌中1类和2类整合子的流行。

结果：
在72个确认的铜绿假单胞菌分离株中，50％来自ICU患者。抗菌敏感性模式显示，分离株对头孢他啶的耐药性最高（76.4％），粘菌素是最有效的抗生素（100％），I类和II类整合子的分子分析显示55.5％和29.1％的菌株分别呈阳性，比例和比例在整合子阳性菌株中，MDR分离株显着高于73.6％，而阴性菌株为22.9％。我们的结果显示1级和2级整合子与MDR铜绿假单胞菌分离株之间存在相关性。根据整合子在获取和传播抗生素抗性基因中的重要性，建议采用抗生素监测程序的性能和研究整合子的作用来控制抗生素抗性基因的传播。

OBJECTIVES:
The role of integrons in the transfer of antibiotic resistance is one of the important issues, therefore, this study is aimed to investigate antibiotic resistance pattern and prevalence of class 1 and 2 integrons in P. aeruginosa isolated.

RESULTS:
Out of 72 confirmed P. aeruginosa isolates, 50% were from ICU patients. Antibacterial susceptibility pattern showed that isolates were most resistant to ceftazidime (76.4%) and colistin was the most effective antibiotic (100%) and molecular analysis of class I and II integrons showed 55.5% and 29.1% of isolates were positive, respectively and the proportions of MDR isolates were significantly higher among integron-positive isolates with 73.6% compared to negative isolates with 22.9%. Our results showed that there was a correlation among class 1 and 2 integrons with MDR P. aeruginosa isolates. According to the importance of integrons in acquisition and dissemination of antibiotics resistance genes, the performance of antibiotic surveillance programs and investigating the role of integrons is recommended to control the spreading of antibiotics resistance genes.

https://www.ncbi.nlm.nih.gov/pubmed/30419962