发布者:抗性基因网 时间:2019-01-30 浏览量:851
摘要
在这项研究中,我们采用了具有acs-22突变的秀丽隐杆线虫(Caenorhabditis elegans)来检查肠屏障功能缺陷对纳米聚苯乙烯颗粒的毒性和易位的体内作用。 acs-22的突变导致肠屏障缺陷。 长时间暴露后,浓度≥1μg/ L的纳米聚苯乙烯颗粒可能对acs-22突变线虫产生毒性。 acs-22突变导致纳米聚苯乙烯颗粒通过肠道屏障在纳米聚苯乙烯颗粒(1μg/ L)暴露的线虫中转移到靶器官中。 长时间暴露后,纳米聚苯乙烯颗粒(1μg/ L)失调了控制氧化应激和激活Nrf信号通路表达所需的一些基因的表达。 因此,在某些病理条件下,我们的结果表明纳米塑料颗粒在长期暴露后对生物体的预测环境浓度具有潜在的毒性。
In this study, we employed Caenorhabditis elegans with acs-22 mutation to examine the in vivo effect of functional deficit in intestinal barrier on toxicity and translocation of nanopolystyrene particles. Mutation of acs-22 leads to deficit in intestinal barrier. After prolonged exposure, nanopolystyrene particles at concentrations ≥1 μg/L could cause toxicity on acs-22 mutant nematodes. acs-22 mutation resulted in translocation of nanopolystyrene particles into targeted organs through intestinal barrier in nanopolystyrene particles (1 μg/L) exposed nematodes. After prolonged exposure, nanopolystyrene particles (1 μg/L) dysregulated expressions of some genes required for the control of oxidative stress and activated expression of Nrf signaling pathway. Therefore, under certain pathological conditions, our results suggest the potential toxicity of nanoplastic particles at predicted environmental concentration on organisms after long-term exposure.
https://www.ncbi.nlm.nih.gov/pubmed/29936155