目的：
该横断面研究评估了与糖尿病足溃疡（DFU）相关的需氧细菌病原体的分布和抗生素敏感性。

材料和方法：
使用常规培养方法和Kirby-Bauer圆盘扩散法的抗菌敏感性处理来自140个具有不同Wagner等级的DFU的两个拭子样品用于鉴定。

结果：
发现总共125个（89.29％）样品对培养的细菌呈阳性。在血糖水平> 200 mg / dL的个体中发现阳性培养的发生率较高（94.32％）。在Wagner 2级DFU中观察到最高数量的培养阳性病例（45％）。总感染率为83.20％（104）的单一微生物和16.80％（21）样品中的多微生物。金黄色葡萄球菌（21.09％）和铜绿假单胞菌（19.05％）是最常见的分离株。利奈唑胺（100％）和亚胺培南（75.70％）分别是抗革兰氏阳性和革兰氏阴性菌株的最有效的抗菌剂。

结论：
结果显示细菌对抗微生物剂的抗性总体上增加，并强调抗菌药物敏感性模式在选择合适的抗生素以进行合理抗生素治疗中的重要性。

OBJECTIVE:
This cross-sectional study assesses the profile and antibiotic susceptibility of aerobic bacterial pathogens associated with diabetic foot ulcers (DFUs).

MATERIALS AND METHODS:
Two swab samples from 140 DFUs with various Wagner grades were processed for identification using routine culture methods and antimicrobial susceptibility by Kirby-Bauer disc diffusion method.

RESULTS:
A total of 125 (89.29%) samples were found to be positive for bacteria on culture. A higher incidence of positive culture (94.32%) was found in individuals with a blood sugar level > 200 mg/dL. The highest number of culture-positive cases was observed in Wagner grade 2 DFUs (45%). Overall infection was monomicrobial in 83.20% (104) and polymicrobial in 16.80% (21) of samples. Staphylococcus aureus (21.09%) and Pseudomonas aeruginosa (19.05%) were the most common isolates. Linezolid (100%) and imipenem (75.70%) were the most effective antimicrobial agents against gram-positive and gram-negative isolates, respectively.

CONCLUSIONS:
The results show an overall increase in bacterial resistance to antimicrobial agents and emphasize the importance of an antimicrobial susceptibility pattern in the selection of appropriate antibiotic(s) to institute the rational antibiotic therapy.

https://www.ncbi.nlm.nih.gov/pubmed/31184594