摘要

    非鲍曼不动杆菌属正在成为医院感染的常见病原体。此外，属于这一类细菌的临床分离株通常对一种或多种抗生素具有抗性。尚未整体研究有关不同非鲍曼不动杆菌物种中抗生素抗性基因的当前信息。因此，我们基于发表的文章和基因组序列中可用的信息，对非鲍曼不动杆菌病原体的抗药性进行了比较研究。我们搜索了GenBank中保存的可用文献和序列，以鉴定A. calcoaceticus，A。lwoffii，A。junii，A。soli，A。ursingii，A。bereziniae，A。nosocomialis，A。portensis，A。的抗性基因含量。瓜拉，A. baylyi，A. calcoaceticus，A.分散，A. johnsonii，A. junii，A. lwoffii，A. nosocomialis，A. oleivorans，A. oryzae，A. pittii，A. radioresisttens和A.威尼斯人。最常见的基因是编码不同β-内酰胺酶的基因，包括碳青霉烯酶基因blaNDM-1和blaOXA-58。皮氏假单胞菌是据报道具有最多β-内酰胺酶抗性基因的物种。通常发现的其他基因包括编码一些氨基糖苷修饰酶的基因，最常见的是aph（6）-Id，ant（3″）-IIa和aph（3″）-Ib，以及外排泵。最普遍发现编码AdeABC，AdeFGH和AdeIJK外排泵的全部或部分基因。本文纳入了有关非鲍曼不动杆菌抗性基因的所有当前信息。比较不同的抵抗组表明存在的基因存在相似性，但是根据病原体的不同，也可能存在明显的差异，这些差异可能会影响治疗的效率。本文是有关非鲍曼不动杆菌抗药性的综合资源。

    Acinetobacter non-baumannii species are becoming common etiologic agents of nosocomial infections. Furthermore, clinical isolates belonging to this group of bacteria are usually resistant to one or more antibiotics. The current information about antibiotic resistance genes in the different A. non-baumannii species has not yet been studied as a whole. Therefore, we did a comparative study of the resistomes of A. non-baumannii pathogens based on information available in published articles and genome sequences. We searched the available literature and sequences deposited in GenBank to identify the resistance gene content of A. calcoaceticus, A. lwoffii, A. junii, A. soli, A. ursingii, A. bereziniae, A. nosocomialis, A. portensis, A. guerrae, A. baylyi, A. calcoaceticus, A. disperses, A. johnsonii, A. junii, A. lwoffii, A. nosocomialis, A. oleivorans, A. oryzae, A. pittii, A. radioresistens, and A. venetianus. The most common genes were those coding for different β-lactamases, including the carbapenemase genes blaNDM-1 and blaOXA-58. A. pittii was the species with the most β-lactamase resistance genes reported. Other genes that were commonly found include those encoding some aminoglycoside modifying enzymes, the most common being aph(6)-Id, ant(3″)-IIa, and aph(3″)-Ib, and efflux pumps. All or part of the genes coding for the AdeABC, AdeFGH, and AdeIJK efflux pumps were the most commonly found. This article incorporates all the current information about A. non-baumannii resistance genes. The comparison of the different resistomes shows that there are similarities in the genes present, but there are also significant differences that could impact the efficiency of treatments depending on the etiologic agent. This article is a comprehensive resource about A. non-baumannii resistomes.

    https://www.mdpi.com/2079-6382/10/1/16