摘要

    人类活动对抗生素和抗生素抗性基因（ARG）的迁移和转化具有非常重要的影响。在本研究中，选择了位于三峡水库地区的长寿湖来研究重金属，抗生素和ARGs的丰度。此外，评估了抗生素的环境风险，并评估了重金属与抗生素/ ARG之间的关系。在长寿湖生态水产养殖区观察到较高浓度的抗生素和ARGs。结果表明，四环素和磺胺甲恶唑的生态风险相对高于其他抗生素。累积风险商的结果表明，生态水产养殖区（C1和C3站点）的目标抗生素严重威胁着长寿湖的生态环境，沉积物环境中的抗生素污染不容忽视。特别是对于四环素ARG，外排泵基因（tetA，tetC和tetG）在P <0.05水平上呈正相关，除tetQ外，核糖体保护蛋白基因之间也有很强的相关性。长寿湖重金属和抗生素的共同污染可能是由于该湖初期的网箱养殖。此外，长寿湖ARGs /抗生素与重金属之间存在显着的正相关，突出了重金属对ARGs /抗生素的潜在压力。

    Human activities have very important influence on the migration and transformation of antibiotics and antibiotic resistance genes (ARGs). In the present study, Changshou Lake, located in the Three Gorges Reservoir area, was selected to investigate the abundance of heavy metals, antibiotics and ARGs. In addition, the environmental risks of the antibiotics were evaluated and the relationships between heavy metals and antibiotics/ARGs were assessed. Higher concentrations of antibiotics and ARGs were observed in the ecological aquaculture area of the Changshou Lake. The results suggested that the ecological risk of tetracycline and sulfamethoxazole was relatively higher than that of other antibiotics. The results of the cumulative risk quotient showed that the target antibiotics of the ecological aquaculture area (sites C1 and C3) seriously threaten the ecological environment of Changshou Lake, and antibiotic pollution in the sediment environment cannot be ignored. Especially for the tetracycline ARGs, there was a positive relationship among efflux pump genes (tetA, tetC and tetG) at the P < 0.05 level, and there was also a strong correlation between the ribosomal protection protein genes, except tetQ. The joint pollution of heavy metals and antibiotics in Changshou Lake may be due to the cage aquaculture in the early stage of the lake. In addition, positive significant correlations were observed between ARGs/antibiotics and heavy metals in Changshou Lake, highlighting the potential pressures of heavy metals on the ARGs/antibiotics.

    https://www.sciencedirect.com/science/article/abs/pii/S1470160X20302120