摘要

  约氏不动杆菌的研究严重不足，其种群结构和抗生素抗性基因 (ARG) 的存在非常不确定。 我们的系统地理学分析表明，洲际传播频繁发生，不同的谱系在单个国家内传播； 值得注意的是，临床和非临床菌株彼此之间没有很好的区分。 重要的是，在该物种中，重组是单核苷酸多态性的重要来源。 此外，我们的结果表明，该物种可能是 ARG 的重要储存库，因为它具有大量的 ARG，其中许多显示出水平基因转移的信号。 因此，这项研究清楚地指出了约氏曲霉菌的临床重要性以及迫切需要更好地了解其基因组多样性。

  Acinetobacter johnsonii has been severely understudied and its population structure and the presence of antibiotic resistance genes (ARGs) are very much uncertain. Our phylogeographical analysis shows that intercontinental transmission has occurred frequently and that different lineages are circulating within single countries; notably, clinical and nonclinical strains are not well differentiated from one another. Importantly, in this species recombination is a significant source of single nucleotide polymorphisms. Furthermore, our results show this species could be an important reservoir of ARGs since it has a significant amount of ARGs, and many of them show signals of horizontal gene transfer. Thus, this study clearly points out the clinical importance of A. johnsonii and the urgent need to better appreciate its genomic diversity.

  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333577/