摘要

       由严重急性呼吸系统综合症冠状病毒-2 (SARS-CoV-2) 引起的 2019 年冠状病毒病 (COVID-19) 问题对全球健康造成了巨大威胁。为了遏制 COVID-19 的传播，大量的消毒剂和抗生素被用于公共卫生。因此，消毒剂和抗生素的浓度在各种环境中迅速增加，包括废水、地表水、土壤和沉积物。本研究的目的是通过总结消毒剂和抗生素的利用、环境发生、分布和毒性来分析它们对生态环境的潜在影响。该论文强调了消毒剂和抗生素对抗生素抗性基因（ARG）甚至抗生素抗性细菌（ARB）的促进作用。科学证据表明，消毒剂和抗生素的高浓度和高剂量通过水平基因转化和垂直基因转化促进了抗菌素耐药性的演变，从而威胁到人类健康。进一步的关注应该更多地关注消毒剂、抗生素、抗生素抗性基因（ARG）甚至抗生素抗性细菌（ARB）在人体中的富集、生物积累和生物放大。

       The issue of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has created enormous threat to global health. In an effort to contain the spread of COVID-19, a huge amount of disinfectants and antibiotics have been utilized on public health. Accordingly, the concentration of disinfectants and antibiotics is increasing rapidly in various environments, including wastewater, surface waters, soils and sediments. The aims of this study were to analyze the potential ecological environment impacts of disinfectants and antibiotics by summarizing their utilization, environmental occurrence, distribution and toxicity. The paper highlights the promoting effects of disinfectants and antibiotics on antibiotic resistance genes (ARGs) and even antibiotic resistant bacteria (ARB). The scientific evidences indicate that the high concentration and high dose of disinfectants and antibiotics promote the evolution toward antimicrobial resistance through horizontal gene transformation and vertical gene transformation, which threaten human health. Further concerns should be focused more on the enrichment, bioaccumulation and biomagnification of disinfectants, antibiotics, antibiotic resistance genes (ARGs) and even antibiotic resistant bacteria (ARB) in human bodies.

https://enveurope.springeropen.com/articles/10.1186/s12302-021-00456-4