摘要

       抗生素和抗生素抗性基因 (ARG) 高度关注新兴植物。污水处理厂 (WWTP) 被认为是环境中抗生素和 ARG 最重要的人为来源之一。选取某市6个污水处理厂分别对进水和出水中的抗生素和ARGs进行调查。污水处理厂共检出7类73种抗生素。这些抗生素的总浓度在490.2-2288.6 ng·L-1之间，其中氧氟沙星、马丙沙星和罗红霉素是进水中最常检测到的抗生素。污水处理厂间抗生素去除效率存在显着差异，污水中抗生素总浓度在260.2-1464.3 ng·L-1之间。出水以大环内酯类和喹诺酮类为主，出水抗生素浓度高于进水。在污水处理厂中检测到 10 种 ARGs。其中sul Ⅰ分布最广，绝对丰度为2.4×105-5.4×106拷贝·mL-1。在工业废水和生活废水之间没有观察到 ARG 丰度的显着差异。此外，在污水处理厂处理后，ARG 丰度与抗生素浓度之间的相关性减弱。

       Antibiotics and antibiotic resistance genes (ARGs) are highly concerning emerging polltants. Wastewater treatment plants (WWTPs) are considered to be one of the most important anthropogenic sources of antibiotics and ARGs in the environment. Six WWTPs of a city were selected to investigate the antibiotics and ARGs in the influents and effluents, respectively. In total, 73 kinds antibiotics belonging to 7 classes were detected in WWTPs. The total concentration of those antibiotics ranged between 490.2-2288.6 ng·L-1, and ofloxacin, maprofloxacin, and roxithromycin were the most frequently detected antibiotics in the influents. A dramtic difference was observed in the antibiotic removal efficiency among the WWTPs, and the total antibiotic concentration in the effluents ranged between 260.2-1464.3 ng·L-1. Macrolides and quinolones are the main classes in the effluents, and the antibiotic concentration in the effluents was higher than that in the influents. Ten kinds of ARGs were detected in the WWTPs. Among these, sul Ⅰ was the most widely prevalent with an absolute abundance of 2.4×105-5.4×106 copies·mL-1. No significant difference in ARG abundance was observed between industrial wastewater and domesic wastewater. Furthermore, the correlation between ARG abundance and antibiotic concentrations weakened after treatment in the WWTPs.

https://europepmc.org/article/med/33372483