摘要

       抗菌素耐药性是对全球公共卫生最紧迫的威胁之一，因为它可能导致人类和牲畜的高发病率、高死亡率和医疗成本。 在反刍动物中，瘤胃微生物组携带大量抗菌素耐药基因（ARGs），这些基因可以通过唾液传播到环境中，或者通过瘤胃微生物生物量流向后肠并通过粪便释放。 已经报道了瘤胃微生物中 ARGs 的发生和分布，揭示了外部刺激（例如，抗菌药物和饮食成分）对瘤胃抗菌素耐药性的影响。 然而，宿主对瘤胃抗性组的影响及其相互作用在很大程度上仍然未知。 在这里，我们使用宏基因组测序研究了瘤胃抗性组及其与宿主采食量和乳蛋白产量的关系。 

       Antimicrobial resistance is one of the most urgent threat to global public health, as it can lead to high morbidity, mortality, and medical costs for humans and livestock animals. In ruminants, the rumen microbiome carries a large number of antimicrobial resistance genes (ARGs), which could disseminate to the environment through saliva, or through the flow of rumen microbial biomass to the hindgut and released through feces. The occurrence and distribution of ARGs in rumen microbes has been reported, revealing the effects of external stimuli (e.g., antimicrobial administrations and diet ingredients) on the antimicrobial resistance in the rumen. However, the host effect on the ruminal resistome and their interactions remain largely unknown. Here, we investigated the ruminal resistome and its relationship with host feed intake and milk protein yield using metagenomic sequencing.

https://animalmicrobiome.biomedcentral.com/articles/10.1186/s42523-021-00081-9