摘要

       目前动物粪便处理的工作不符合要求的标准，因此不应该反映抗生素耐药性控制的实际表现。 因此，本研究以磺胺甲恶唑（SMX）为典型抗生素进行了温控好氧堆肥。 四种不同处理的结果表明，温度、含水量、C/N 比、EC 和 pH 值均无显着差异（p > 0.05）。 抗生素抗性基因 (ARGs) 在嗜热期的前 10 天显着减少，但 sul1 和 sul2 的丰度在 30 天后大幅增加。 此外，在堆肥后期，ARGs 之间密切相关。 堆肥特性的显着影响，尤其是温度对细菌群落的影响，然后对 ARGs 丰度产生积极影响。 这些发现证明标准堆肥仍然不足以控制抗生素耐药性。 

       Current work for animal manure processing is not up to the required standards and hence are not supposed to reflect the actual performance in antibiotic resistance control. As a result, this study carried out temperature-controlled aerobic composting, with sulfamethoxazole (SMX) as a typical antibiotic. The results of four different treatments demonstrated that temperature, water content, C/N ratio, EC, and pH showed no significant (p > 0.05) difference. Antibiotic resistance genes (ARGs) significantly decreased in the initial 10 days of the thermophilic phase, but the abundance of sul1 and sul2 increased greatly after 30 days. Moreover, ARGs were closely related with each other during the late stages of composting. A noteworthy effect of composting properties, especially temperature on bacterial community, which then had a positive effect on ARGs abundances. These findings provided evidence that the standard composting was still insufficient to control antibiotic resistance.

https://www.sciencedirect.com/science/article/abs/pii/S0960852420316771