软骨退化是骨关节炎 (OA) 的标志。 Aggrecan 是关节软骨细胞外基质 (ECM) 的主要蛋白聚糖，被 ADAMTS-5 降解，导致 ARGS-G2 片段释放到滑液和循环中。 目的是使用 huARGS 免疫测定法量化 OA 患者血清中的 ARGS-G2。

       Cartilage degradation is a hallmark of osteoarthritis (OA). Aggrecan, a major proteoglycan of articular cartilage extracellular matrix (ECM), is degraded by ADAMTS-5 resulting in the release of ARGS-G2 fragments to synovial fluid and circulation. The aim was to quantify ARGS-G2 in the serum of OA patients using the huARGS immunoassay.

https://www.sciencedirect.com/science/article/pii/S266591312100025X