摘要

       水产养殖在世界范围内呈上升趋势，抗生素的使用正在促进更高的生产强度。 然而，最近的研究结果表明，抗生素的使用是以增加抗生素耐药性为代价的。 然而，口服抗生素对鱼肠道中微生物抗性基因流动性的影响尚不清楚。 在本研究中，Piaractus mesopotamicus 被用作模型，使用宏基因组学方法评估抗菌氟苯尼考对肠道微生物组以及抗生素抗性基因 (ARG) 和移动遗传元件 (MGE) 多样性的影响。 

       Aquaculture is on the rise worldwide, and the use of antibiotics is fostering higher production intensity. However, recent findings suggest that the use of antibiotics comes at the price of increased antibiotic resistance. Yet, the effect of the oral administration of antibiotics on the mobility of microbial resistance genes in the fish gut is not well understood. In the present study, Piaractus mesopotamicus was used as a model to evaluate the effect of the antimicrobial florfenicol on the diversity of the gut microbiome as well as antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) using a metagenomic approach.

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-019-0632-7#Sec14