摘要

       当细菌对两种类型的化合物具有抗性或耐受性基因时，抗菌杀菌剂和金属可以共同选择抗生素抗性。 尽管有大量案例研究，但缺乏关于质粒和染色体上此类基因共存的系统和定量数据，以及关于倾向于携带对此类化合物的抗性基因的环境和细菌分类群的知识。 这有效地防止了风险情景的识别。 因此，我们旨在确定倾向于同时出现的杀生物剂/金属抗性基因 (BMRG) 和抗生素抗性基因 (ARG) 的一般模式。 我们还旨在量化不同环境和分类群中抗性基因的共存情况，并研究携带两种类型基因的质粒在多大程度上是结合的和/或携带毒素-抗毒素系统的。 

       Antibacterial biocides and metals can co-select for antibiotic resistance when bacteria harbour resistance or tolerance genes towards both types of compounds. Despite numerous case studies, systematic and quantitative data on co-occurrence of such genes on plasmids and chromosomes is lacking, as is knowledge on environments and bacterial taxa that tend to carry resistance genes to such compounds. This effectively prevents identification of risk scenarios. Therefore, we aimed to identify general patterns for which biocide/metal resistance genes (BMRGs) and antibiotic resistance genes (ARGs) that tend to occur together. We also aimed to quantify co-occurrence of resistance genes in different environments and taxa, and investigate to what extent plasmids carrying both types of genes are conjugative and/or are carrying toxin-antitoxin systems.

https://link.springer.com/article/10.1186/s12864-015-2153-5#Sec2