摘要

       尽管抗生素耐药性对全世界人类和环境健康构成了日益严重的威胁，但噬菌体（噬菌体）对环境中抗生素耐药基因 (ARG) 的获取和传播的贡献尚未得到广泛探索。 在这项研究中，对来自不同海洋栖息地的几种病毒组进行了综合分析，以研究噬菌体是否携带 ARG。 该分析提供了强有力的证据，证明来自海洋栖息地的噬菌体是 ARG 的潜在储存库。 事实上，在所有分析的海洋病毒组中都发现了赋予氨基香豆素、杆菌肽抗性和多药抗性（特别是 mexB 基因）的基因。 鉴于此，考虑到它们的全球分布，不应低估噬菌体作为 ARG 库的作用。

       Although antibiotic resistance represents a significant and growing threat to human and environmental health worldwide, the contribution of bacteriophages (phages) to the acquisition and spread of antibiotic resistance genes (ARGs) in the environment has not been extensively explored. In this study, a comprehensive analysis of several viromes from diverse marine habitats was performed to investigate whether or not phages carry ARGs. The analysis provides strong evidence that phages from marine habitats are potential reservoirs of ARGs. In fact, genes conferring resistance to aminocoumarin, bacitracin and multidrug resistance (particularly the mexB gene) were found in all analyzed marine viromes. Given this, the role of phages as reservoirs of ARGs should not be underestimated considering their global distribution.

https://www.sciencedirect.com/science/article/abs/pii/S0048969718345224