摘要

       多重耐药性质粒 pAQU1 和 IncFIB 在极低选择压力下在细菌群体中的持久性进行了检查。 我们在此证明了这些质粒不仅稳定地保留在原始宿主中，而且还处于转接合子中，即使在处于不可培养状态之后也是如此。 在含有具有 pAQU1 的少女光杆菌 04Ya311 的海水缩影中，在 30 天的饥饿期间没有观察到 pAQU1 的显着损失。 大肠杆菌中 pAQU1 和 IncFIB 的拷贝数是恒定的。 本研究的结果表明，这些质粒能够在抗生素选择压力低的寡营养条件下保留在各种细菌中。

       The persistence of the multi-drug resistance plasmids pAQU1 and IncFIB was examined in bacterial populations under very low selective pressure. We herein demonstrated that these plasmids stably remained not only in the original host, but also in a transconjugant, even after being in a non-culturable state. In seawater microcosms containing Photobacterium damselae 04Ya311 possessing pAQU1, no significant loss of pAQU1 was observed during a 30-d starvation period. The copy numbers of pAQU1 and IncFIB in E. coli were constant. The results of the present study suggest that these plasmids have the ability to remain among various bacteria under oligotrophic conditions with low antibiotic selection pressure.

https://www.jstage.jst.go.jp/article/jsme2/advpub/0/advpub_ME15122/_article/-char/ja/