摘要

       关节软骨中聚集蛋白聚糖的蛋白水解降解是骨关节炎 (OA) 的标志性特征。 本研究旨在开发一种灵敏的酶联免疫吸附试验 (ELISA)，用于检测人血清和尿液中聚集蛋白聚糖酶裂解的片段，以促进骨关节炎的聚集蛋白聚糖酶抑制剂的临床开发。

       Proteolytic degradation of aggrecan in articular cartilage is a hallmark feature of osteoarthritis (OA). The present study was aimed at developing a sensitive enzyme linked immunosorbent assay (ELISA) for the detection of aggrecanase-cleaved fragments of aggrecan in human serum and urine to facilitate the clinical development of aggrecanase inhibitors for OA.

https://www.sciencedirect.com/science/article/pii/S1063458410002141