摘要

       最重要的进化力量之一是重组，它通过遗传物质的交换和现有突变的改组来增加遗传多样性并促进适应。例如，有关重组的知识是了解基因组结构（Reich 等，2001）、表型多样性（Zhang 等，2002）和多种遗传疾病（Daly 等，2001）的基础。事实上，应该考虑重组以正确研究分子进化并进行系统发育推断（例如，Schierup 和 Hein，2000；Anisimova 等，2003；Arenas 和 Posada，2010c）。重组进化历史通常由祖先重组图 (ARG) (Griffiths and Marjoram, 1997) 表示，图 1 显示了一个说明性示例。显式 ARG 和 ARG 表示的复杂性。本一般性评论的目的是描述 ARG 的重要性和应用。

       One of the most important evolutionary forces is recombination, which increases genetic diversity and promotes adaptation through the exchange of genetic material and the reorganization of existing mutations. For example, knowledge about recombination is the basis for understanding genome structure (Reich et al., 2001), phenotypic diversity (Zhang et al., 2002), and a variety of genetic diseases (Daly et al., 2001). In fact, recombination should be considered to correctly study molecular evolution and make phylogenetic inferences (for example, Schierup and Hein, 2000; Anisimova et al., 2003; Arenas and Posada, 2010c). The evolutionary history of recombination is usually represented by the ancestral recombination diagram (ARG) (Griffiths and Marjoram, 1997). Figure 1 shows an illustrative example. Explicit ARG and ARG indicate the complexity. The purpose of this general comment is to describe the importance and application of ARG. 

https://www.frontiersin.org/articles/10.3389/fgene.2013.00206/full?utm_source=newsletter&utm_medium=email&utm_campaign=Genetics-w43-2013