摘要

       抗生素发酵残留物是一种危险废物，由于残留抗生素的存在以及产生抗生素抗性基因（ARGs）的潜在风险。抗生素发酵残留物的适当处理和处置势在必行。在这项研究中，应用电离辐射处理抗生素发酵残留物，并研究了抗生素（红霉素）、ARGs（ermB 和 ermF）和抗生素抗性细菌的去除效率。实验结果表明，当剂量为10kGy时，抗生素发酵残留物中红霉素A的含量下降了86%。此外，在 10kGy 照射下，ermB 和 ermF 的丰度降低了 89% 和 98%。 10kGy辐照后，99%以上的细菌被去除，抗生素耐药菌（ARB）低于检测限。电离辐射工艺是同时去除抗生素发酵残留物中的抗生素和灭活 ARGs 和 ARB 的有前途的技术。此外，10kGy辐照对抗生素发酵残渣的大分子有机物（蛋白质、多糖）无显着影响，表明处理后的发酵残渣可用作肥料，为回收利用的发展提供技术支持。抗生素制药厂的经济。 

       Antibiotic fermentation residue is a hazardous waste due to the existence of residual antibiotics and the potential risk of antibiotic resistance genes (ARGs). Proper handling and disposal of antibiotic fermentation residues is imperative. In this study, ionizing radiation was used to treat antibiotic fermentation residues, and the removal efficiency of antibiotics (erythromycin), ARGs (ermB and ermF) and antibiotic-resistant bacteria was studied. The experimental results showed that when the dose was 10kGy, the content of erythromycin A in the antibiotic fermentation residue decreased by 86%. In addition, under 10kGy irradiation, the abundance of ermB and ermF decreased by 89% and 98%. After 10kGy irradiation, more than 99% of the bacteria were removed, and the antibiotic-resistant bacteria (ARB) were below the detection limit. The ionizing radiation process is a promising technology that simultaneously removes antibiotics from antibiotic fermentation residues and inactivates ARGs and ARBs. In addition, 10kGy irradiation has no significant effect on the macromolecular organics (proteins, polysaccharides) of antibiotic fermentation residues, indicating that the treated fermentation residues can be used as fertilizers, providing technical support for the development of recycling. The economics of antibiotic pharmaceutical factories.

https://www.sciencedirect.com/science/article/abs/pii/S0956053X1830727X