摘要

       在 35 名患有嗜银性谷物病 (AgD) 的受试者中分析了载脂蛋白 E (ApoE) 基因型。 神经病理学上，所有病例的特征是海马和内嗅或海马旁皮质中大量嗜银颗粒。 我们发现 AgD 患者的 ApoE ɛ4 等位基因频率为 0.007，这与年龄匹配的阿尔茨海默病 (AD) 患者 (0.24) 中报告的 ɛ4 等位基因频率显着不同，但与年龄匹配的对照 (0.09) 不同。 我们得出结论，ApoE ɛ4 等位基因不构成 AgD 发展的风险因素。 我们的研究结果进一步表明，AgD 是一种进行性疾病，通过形态学和遗传标准与 AD 相区分。

       The apolipoprotein E (ApoE) genotype was analyzed in 35 subjects with argyrophilic cereal disease (AgD). Neuropathologically, all cases were characterized by a large number of silver-philic particles in the hippocampus and entorhinal or parahippocampal cortex. We found that the ApoE ɛ4 allele frequency in AgD patients is 0.007, which is significantly different from the ɛ4 allele frequency reported in age-matched Alzheimer's disease (AD) patients (0.24), but it is significantly different from the age-matched control ( 0.09) Different. We conclude that the ApoE ɛ4 allele does not constitute a risk factor for the development of AgD. Our findings further indicate that AgD is a progressive disease, which is distinguished from AD by morphological and genetic criteria. 

https://link.springer.com/article/10.1007%2Fs004010050887