摘要

       多药耐药 (MDR) 质粒经常携带抗生素耐药基因，赋予不同的耐药机制。 我们在这里表明，在大肠杆菌中选择 RK2 质粒的抗生素浓度取决于耐药性的社会性：自私耐药性（外排泵）的选择发生在非常低的药物浓度下，仅为质粒 MIC 的 1.3% --free 抗生素敏感菌株，而协同耐药性（修饰酶）的选择发生在药物浓度超过无质粒菌株的 MIC 时。

       Multidrug resistance (MDR) plasmids often carry antibiotic resistance genes, conferring different resistance mechanisms. We show here that the antibiotic concentration of the RK2 plasmid in E. coli depends on the social nature of resistance: the selection of selfish resistance (efflux pump) occurs at very low drug concentrations, which is only 1.3 of the plasmid MIC. % --free antibiotic-sensitive strains, and the selection of co-resistance (modified enzyme) occurs when the drug concentration exceeds the MIC of the plasmid-free strain. 

https://journals.asm.org/doi/full/10.1128/AAC.02441-15