摘要

       抗生素抗性基因（ARGs）的环境行为和迁移模式引起了相当大的研究兴趣。然而，关于相应和非相应污染物对沿海环境中 ARGs 归宿的影响的研究很少。在本研究中，在相应和非相应污染物的背景下，分析了莱州湾水和沉积物样品中 intI1、sul1、sul2、qnrS 和 aac(6')-Ib 的分布。 intI1、sul1和sul2基因的丰度从内河口向沿海地区呈明显下降趋势。沉积物中 sul1/sul2 与磺胺类抗生素残留、intI1 与 sul1/sul2 丰度之间存在强正相关。统计分析表明，非对应污染物与 ARG 丰度部分相关。这些结果表明，非对应污染物可能对莱州湾 ARGs 和 intI1 的丰度有直接或间接的影响。

       The environmental behavior and migration patterns of antibiotic resistance genes (ARGs) have aroused considerable research interest. However, there are few studies on the effects of corresponding and non-corresponding pollutants on the fate of ARGs in the coastal environment. In this study, in the context of corresponding and non-corresponding pollutants, the distribution of intI1, sul1, sul2, qnrS and aac(6')-Ib in the water and sediment samples of Laizhou Bay was analyzed. The abundance of intI1, sul1 and sul2 genes showed a significant downward trend from inland estuaries to coastal areas. There is a strong positive correlation between the abundance of sul1/sul2 and sulfa antibiotic residues, intI1 and sul1/sul2 in the sediments. Statistical analysis shows that non-corresponding pollutants are partially related to ARG abundance. These results indicate that non-corresponding pollutants may have direct or indirect effects on the abundance of ARGs and intI1 in Laizhou Bay. 

https://www.sciencedirect.com/science/article/abs/pii/S0025326X18300626