摘要

       细菌病原体的抗微生物药物耐药性是一个与高发病率和死亡率相关的挑战。 革兰氏阳性和阴性细菌的多药耐药模式难以治疗，甚至可能无法用常规抗生素治疗。 目前缺乏有效的治疗方法，缺乏成功的预防措施，并且只有少数新抗生素，需要开发新的治疗方案和替代抗菌疗法。 生物膜涉及多药耐药性，可能对感染控制提出挑战。 还讨论了毒力、金黄色葡萄球菌、艰难梭菌感染、耐万古霉素肠球菌和急诊科的控制。 

       Antimicrobial resistance of bacterial pathogens is a challenge associated with high morbidity and mortality. The multidrug resistance pattern of Gram-positive and negative bacteria is difficult to treat, and may even be impossible to treat with conventional antibiotics. At present, there is a lack of effective treatment methods, a lack of successful preventive measures, and only a few new antibiotics. It is necessary to develop new treatment options and alternative antibacterial therapies. Biofilms involve multidrug resistance and may pose challenges to infection control. Also discussed are virulence, Staphylococcus aureus, Clostridium difficile infection, Vancomycin-resistant Enterococcus, and emergency department control. 

https://www.sciencedirect.com/science/article/pii/S1876034116301277