摘要

       一名 70 岁男性开始出现运动不能、四肢强直、手指震颤、垂直外眼运动障碍和颈部肌张力障碍，进展缓慢。脑CT扫描和磁共振图像显示额叶轻微萎缩，侧脑室轻微扩大。长谷川的痴呆评定量表修订版给出了 11/30 分的中等分数。 76岁死于肺炎。临床诊断为进行性核上性麻痹（PSP）。然而，没有PSP的神经病理学特征。神经病理学上，帕金森病被诊断出来。此外，通过 Gallyas-Braak 方法，灰质中的许多嗜银颗粒 (ArG) 被染色，特别是在岛叶、杏仁核、海马、海马旁回、外侧枕颞回和黑质中。我们认为 ArGs 可以改变帕金森病的症状，并且使用 ArGs 的帕金森病可能表现出类似 PSP 的临床过程。

       A 70-year-old man began to experience motor immobility, rigid limbs, finger tremor, vertical external eye movement disorder, and cervical dystonia, and his progress was slow. Brain CT scans and magnetic resonance images showed slight atrophy of the frontal lobe and slight enlargement of the lateral ventricles. The revised version of Hasegawa's Dementia Rating Scale gives a middle score of 11/30. Died of pneumonia at the age of 76. The clinical diagnosis was progressive supranuclear palsy (PSP). However, there are no neuropathological features of PSP. Neuropathologically, Parkinson's disease was diagnosed. In addition, by the Gallyas-Braak method, many silver-philic grains (ArG) in gray matter are stained, especially in the insula, amygdala, hippocampus, parahippocampal gyrus, lateral occipitotemporal gyrus, and substantia nigra. We believe that ArGs can change the symptoms of Parkinson's disease, and Parkinson's disease using ArGs may show a clinical course similar to PSP. 

https://www.sciencedirect.com/science/article/abs/pii/S0022510X00003592