摘要

       现代畜牧业经常使用抗生素。 药物动物的粪便用于耕种作物的施肥，这反过来又会导致环境中抗生素抗性基因 (ARG) 的积累。 这是一个潜在的严重公共卫生问题，但涉及 ARG 持久性的细菌分类群的身份尚未确定。 使用土壤肥料微观世界实验，我们研究了（i）不同 ARG 的持久性和（ii）细菌群落成员的动态之间的关系。 我们第一次能够识别出参与肥沃土壤中 ARG 富集的细菌分类群。 它们是肠道相关的梭菌属物种，以及不动杆菌属和假单胞菌属的环境物种，它们都与重要的医院病原体密切相关。 我们的数据为 ARG 可能从农场传播到医疗诊所的途径提供了新线索

       Antibiotics are often used in modern animal husbandry. The manure of medicated animals is used for fertilization of cultivated crops, which in turn leads to the accumulation of antibiotic resistance genes (ARG) in the environment. This is a potentially serious public health problem, but the identity of the bacterial taxa involved in ARG persistence has not been determined. Using soil fertilizer microcosm experiments, we studied the relationship between (i) the persistence of different ARGs and (ii) the dynamics of bacterial community members. For the first time, we were able to identify the bacterial taxa involved in ARG enrichment in fertile soil. They are the intestinal-related Clostridium species, as well as the environmental species of Acinetobacter and Pseudomonas, which are closely related to important hospital pathogens. Our data provides new clues as to how ARG may spread from the farm to the medical clinic 

https://sfamjournals.onlinelibrary.wiley.com/doi/abs/10.1111/1462-2920.13337