摘要
      抗生素耐药性被认为是21世纪普遍存在的健康威胁，其分布甚至发展主要由水性介质介导。传统方法的消毒过程仍然是应对水性基质特别是废水中此类危机的最有前途的选择。鉴于消毒的有效性和质量非常重要，本文旨在系统地回顾和讨论臭氧氧化（作为大规模应用的主要消毒剂之一）在去除水溶液中抗生素抗性细菌（ARB）和抗生素抗性基因（ARGs）方面的效果，目前尚未有研究报告。为此，在国际数据库中使用适当的关键词进行了一项全面的文献调查，得出了几项研究，涉及臭氧氧化对ARB和ARGs的不同方面和有效程度。结果表明，对于臭氧单独或混合形式的优越性，还没有得出确切的结论。尽管人们对其作用机制仍知之甚少，但对其进行了仔细的评估和讨论。从变性和修复的角度对研究进行的评估表明，臭氧氧化后无法避免再生，尤其是对于一些ARB和ARGs变体。此外，对ARB和ARGs的有效性的比较表明，臭氧氧化对耐药细菌比它们各自的基因更有效。降解效率主要受CT操作参数（即臭氧剂量和接触时间）、固体、碱度、pH以及病原体和基因类型的影响。此外，还对ARB和ARGs去除与应激源（如抗生素残留、重金属、芳香物质、微囊藻毒素、机会性病原体等）之间的相关性进行了综述，为进一步深入研究提供了最佳参考。还报告了未来的前景。
Abstract
Antibiotic resistance is considered a universal health threat of the 21st century which its distribution and even development are mainly mediated by water-based media. Disinfection processes with the conventional methods are still the most promising options to combat such crises in aqueous matrices especially wastewater. Knowing that the extent of effectiveness and quality of disinfection is of great importance, this paper aimed to systematically review and discuss ozonation (as one of the main disinfectants with large scale application) effect on removing antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) from aqueous solutions, for which no study has been reported. For this, a comprehensive literature survey was performed within the international databases using appropriate keywords which yielded several studies involving different aspects and the effectiveness extent of ozonation on ARB & ARGs. The results showed that no definite conclusion could be drawn about the superiority of ozone alone or in a hybrid form. Mechanism of action was carefully evaluated and discussed although it is still poorly understood. Evaluation of the studies from denaturation and repairment perspectives showed that regrowth cannot be avoided after ozonation, especially for some ARB & ARGs variants. In addition, the comparison of the effectiveness on ARB & ARGs showed that ozonation is more effective for resistant bacteria than their respective genes. The degradation efficiency was found to be mainly influenced by operational parameters of CT (i.e. ozone dose & contact time), solids, alkalinity, pH, and type of pathogens and genes. Moreover, the correlation between ARB & ARGs removal and stressors (such as antibiotic residuals, heavy metals, aromatic matters, microcystins, opportunistic pathogens, etc.) has been reviewed to give the optimal references for further in-depth studies. The future perspectives have also been reported.

https://www.sciencedirect.com/science/article/abs/pii/S0048969721064822