摘要
      为了对抗抗生素引起的耐药细菌的滋生和抗生素耐药基因（ARGs）的传播，开发具有消除残留抗生素和抑制ARGs传播特性的多功能非抗生素制剂迫在眉睫。本文通过超声方法将十二烷基硫酸钠（SDS）改性到Fe2O3@MoS2表面，得到Z方案的多功能Fe2O3@MoS2@SDS纳米复合材料。选择Fe2O3@MoS2@SDS（Fe2O3@MoS2和SDS的重量比为1:1）作为最佳试剂。在近红外辐射下，Fe2O3@MoS2@SDS的光热转化效率为45.96%，同时可以产生大量的活性氧。在光热和光动力的协同作用下，Fe2O3@MoS2@SDS对大肠杆菌、耐甲氧西林金黄色葡萄球菌和铜绿假单胞菌的抗菌效率分别可达99.95%、99.97%和99.58%，表明其具有良好的光热光动力治疗（PPT）效果。Fe2O3@MoS2@SDS在降解四环素（TC）方面也表现出光催化活性。可见光照射2h后，TC的降解率可达92.3%。结果表明，可以构建一种有前途的基于Fe2O3@MoS2@SDS复合材料的多功能纳米平台，用于近红外诱导的细菌灭活、抗生素降解和ARGs扩散抑制。
Abstract
To fight the flourishment of drug-resistant bacteria caused by antibiotics and the dissemination of antibiotic resistance genes (ARGs), it is of great urgency to develop multifunctional non-antibiotic agents with residual antibiotics elimination, and ARGs dissemination inhibition properties. Herein, sodium dodecyl sulfate (SDS) was modified onto the surface of Fe2O3 @MoS2 by ultrasonic method to obtain the Z-scheme, multifunctional Fe2O3 @MoS2 @SDS nanocomposites. The Fe2O3 @MoS2 @SDS (weight ratio of Fe2O3 @MoS2 and SDS was 1:1) was selected as the optimal agent. Under NIR irradiation, the Fe2O3 @MoS2 @SDS had a photothermal conversion efficiency of 45.96%, and could generate plenty of reactive oxygen species (ROS) at the same time. Under the synergy of photothermal and photodynamic, the antibacterial efficiency of Fe2O3 @MoS2 @SDS to E. coli, MRSA and P. aeruginosa could reach 99.95%, 99.97% and 99.58%, respectively, indicating excellent photothermal-photodynamic therapy (PPT) effect. The Fe2O3 @MoS2 @SDS also displayed photocatalytic activity in degradation of tetracycline (TC). The degradation rate of TC could reach 92.3% after 2 h of visible light irradiation. The obtained results indicated that a promising Fe2O3 @MoS2 @SDS composite based multifunctional nanoplatform could be constructed for NIR induced bacterial inactivation, antibiotics degradation and ARGs dissemination inhibition.

https://www.sciencedirect.com/science/article/abs/pii/S0927776522005161