摘要
      抗生素抗性基因（ARGs）是一种新出现的环境健康威胁，因为人类微生物组的潜在变化和抗生素抗性细菌的出现选择。抗生素耐药性细菌的增加给全球健康带来了负担。世界卫生组织（WHO）预测，由于抗生素耐药感染导致的死亡人数将增加。由于细菌可以通过水平传播获得ARGs，因此评估来自人类来源的抗生素抗性基因的传播是很重要的。环境中抗生素、抗生素耐药性细菌和基因有几种来源。其中包括废水处理厂、垃圾填埋场渗滤液、农业、动物工业来源和河口。抗生素的使用是一种世界性的做法，导致了抗生素耐药性的演变。我们的综述对ARG和抗生素的多种来源而不是单一来源进行了更全面的研究。此外，我们重点关注ARGs和抗生素的有效监测方法，以及可持续的非生物和生物修复策略，以去除和减少陆地和水生环境中的抗生素和ARGs。此外，我们考虑到对公共卫生的影响，因为如果没有全球跨学科的努力，这个问题就无法解决。
Abstract
Antibiotic Resistant Genes (ARGs) are an emerging environmental health threat due to the potential change in the human microbiome and selection for the emergence of antibiotic resistant bacteria. The rise of antibiotic resistant bacteria has caused a global health burden. The WHO (world health organization) predicts a rise in deaths due to antibiotic resistant infections. Since bacteria can acquire ARGs through horizontal transmission, it is important to assess the dissemination of antibioticresistant genes from anthropogenic sources. There are several sources of antibiotics, antibiotic resistant bacteria and genes in the environment. These include wastewater treatment plants, landfill leachate, agricultural, animal industrial sources and estuaries. The use of antibiotics is a worldwide practice that has resulted in the evolution of resistance to antibiotics. Our review provides a more comprehensive look into multiple sources of ARG's and antibiotics rather than one. Moreover, we focus on effective surveillance methods of ARGs and antibiotics and sustainable abiotic and biotic remediation strategies for removal and reduction of antibiotics and ARGs from both terrestrial and aquatic environments. Further, we consider the impact on public health as this problem cannot be addressed without a global transdisciplinary effort.

https://www.sciencedirect.com/science/article/abs/pii/S0013935122015390