摘要
      微塑料已被证明是细菌病原体和抗生素抗性基因（ARGs）的热点。ARGs在微塑料层中的富集引起了全世界的关注，微塑料层是附着在微塑料表面的各种微生物群落的特定生态位。通过收集属于26种ARG类型的477对ARG丰度数据，基于随机效应模型下的标准化平均差（SMD），我们对水生环境中ARG对微塑料的富集进行了首次荟萃分析，以定量阐明其富集效果，并与非微塑料材料进行了比较。研究发现，在微塑料上富集的ARG比在无机基质（SMD=0.26）和自然水环境（SMD=0.10）上更丰富，但比在天然有机基质上（SMD=-0.52）含量更低。此外，淡水中的微塑料往往比盐水和污水中的微塑性塑料具有更高的ARG富集程度。微塑料层的生物膜形成阶段、结构和成分可能在ARGs的富集中发挥重要作用。
Abstract
Microplastics have been proven to be hotspots of bacterial pathogens and antibiotic resistance genes (ARGs). The enrichment of ARGs in microplastisphere, the specific niche for diverse microbial communities attached to the surface of microplastic, has attracted worldwide attention. By collecting 477 pairs of ARG abundance data belonging to 26 ARG types, based on the standardized mean difference (SMD) under the random effect model, we have performed the first meta-analysis of the ARG enrichment on microplastics in aquatic environments in order to quantitatively elucidate the enrichment effect, with comparison of non-microplastic materials. It was found that ARGs enriched on the microplastics were more abundant than that on the inorganic substrates (SMD = 0.26) and natural water environments (SMD = 0.10), but lower abundant than that on the natural organic substrates (SMD = −0.52). Furthermore, microplastics in freshwater tended to have a higher degree of ARG enrichment than those in saline water and sewage. The biofilm formation stage, structure, and component of microplastisphere may play a significant role in the enrichment of ARGs.

https://www.sciencedirect.com/science/article/abs/pii/S0269749122011058