摘要
      抗生素抗性基因（ARGs）和移动遗传元件（MGEs）是全球新出现的环境和水关系的主要污染物，相关研究的各种研究人员已经报道了这一点。在水体、废水处理系统和河口中观察到ARGs和MGE，表明存在相关风险、耐药细菌/ARGs传播或潜在的健康问题，如果不实施适当的基于研究的策略来清除这些致命的遗传物质，可能会导致环境病原体激增。尽管有报告和以知识为基础的清除战略，但挑战依然存在。本研究旨在评估相关研究的影响/贡献，并强调在应对废水/水体中ARGs/MGE不断扩大的挑战时，有必要采用基于研究的/从业者相结合的方法。该研究描述了对抗生素耐药性决定因素的文献计量评估——科学网上的年度科学出版物、相关文章的年增长率、每次引用的热门文章以及搜索主题和内容回顾分析，以评估ARG/MGE的去除方法。共检索到1301篇废水处理系统文章，日期范围为1997年至2019年。随着文章发表量的增加和总引用率的下降，观察到研究的年增长率为37.82%，R2为0.7863，这表明水体和环境中ARGs/MGEs研究的分散性报告持续存在。尽管有大量关于ARGs和MGE在水关系和废水排放方面的广泛研究和报告，以及基于研究的去除策略，但这些报告的影响尚未在废水系统从业者中得到充分实施。建议通过应用肯定的基于研究的方法，明确实施从环境中去除ARGs/MGE的策略。
Abstract
Antibiotic resistance genes (ARGs) and Mobile genetic elements (MGEs) are major global emerging pollutants of the environment and water nexus which various investigators of related studies have reported. Observing ARGs and MGEs in water bodies, wastewater treatment systems, and estuaries is indicative of relevant risk, resistant bacteria/ARGs spread or potential health concern and may result environmental pathogen bloom if appropriate research-based strategies are not implemented to remove these lethal genetic materials. Despite reports and knowledge-based strategies for removal, the challenge yet persists. This study aims to appraise the impact/contribution of related studies and emphasize the necessity for applying combined research-based/practitioners approach in addressing the expanding challenge of ARGs/MGEs in wastewater/waterbodies. The study describes a bibliometric assessment of antibiotic resistance determinants annual scientific publications on the Web of Science, an annual growth rate of related articles, top articles per citations with search topics and content-review analysis to evaluate the methods of removal of ARGs/MGEs. A total of 1301 articles of wastewater treatment systems were retrieved with date range of 1997–2019. A description of the study Annual Growth Rate of 37.82% at R2 of 0.7863 was observed with an increasing article publication and a decreasing total citation rate indicating persistent reports of dispersion on ARGs/MGEs studies in the water bodies and environment. Although there abound extensive studies and reports of ARGs and MGEs in water nexus and wastewater release with research based removal strategies, the impact of such reports have not been fully actualized amongst wastewater system practitioners. A lucid drive towards implementing ARGs/MGEs removal strategies from the environment by applying affirmed research-based methods are suggestive.

https://www.sciencedirect.com/science/article/pii/S2405844022035411