摘要
      抗微生物耐药性（AMR）的出现是世界范围内一个紧迫而复杂的公共卫生挑战。作为AMR的一个子问题，由于替代药物的不足，抗菌耐药性（ABR）尤其令人担忧。早期的研究表明，ABR不仅受到抗生素的影响，还受到细菌与其环境之间相互作用的影响。因此，为了在特定地区对抗ABR，必须调查当地的环境条件，以全面了解哪些环境因素可能导致ABR，并提出更具针对性的解决方案。本研究调查了长江三角洲抗生素耐药性基因（ARGs）的环境贡献者，ARGs是测量ABR的参数。尽管抗生素和重金属浓度较低，但仍检测到高丰度的ARGs。磷、铬、锰、钙和锶被确定为ARGs的潜在关键贡献者。抑制ARGs可以通过降低地表水中磷的浓度来实现。2A族轻金属（如镁和钙）可以在未来被开发为控制抗生素耐药性的环保试剂。
Abstract
The emergence of antimicrobial resistance (AMR) is an urgent and complex public health challenge worldwide. As a sub-problem of AMR, antibacterial resistance (ABR) is of particular concern due to inadequacy of alternative medication. Earlier studies have shown that ABR is not only impacted by antibiotics, but also affected by the interactions between bacteria and their environments. Therefore, to combat ABR in a specific region, local environmental conditions must be investigated to comprehensively understand which environmental factors might contribute to ABR and propose more tailored solutions. This study surveyed environmental contributors of antibiotic resistance genes (ARGs), the parameter for measuring ABR, in the Yangtze Delta. A high abundance of ARGs was detected, despite low antibiotic and heavy metal concentrations. Phosphorus, chromium, manganese, calcium, and strontium were identified as potential key contributors of ARGs. Suppression of ARGs could be realized through decreasing the concentration of phosphorus in surface water. Group 2A light metals (e.g., magnesium and calcium) could be developed as eco-friendly reagents for controlling antibiotic resistance in the future.

https://www.medrxiv.org/content/10.1101/2022.12.05.22283137v2