摘要
      抗生素在环境中的积累产生了耐多药的“超级细菌”和抗生素耐药性基因（ARGs）。选择一种广泛使用的抗生素氯霉素（CAP）作为模型化合物，研究其在电化学处理过程中的降解。与Ti/PbO2电极相比，所制备的Ti/PbO2-La电极具有更致密的表面和更完整的PbO2晶体结构。La的掺杂增加了起始电位和过电位，增加了氧化峰和还原峰的电流值，降低了阻抗，延长了寿命。在Ti/PbO2–La电极上的CAP降解和TOC去除反应都是主要的动力学反应。CAP降解率随着电流密度的增加而增加，在25 mA cm−2的电流密度下，TOC的去除率最高。电解质浓度在0.050–0.150 mol L−1的范围内影响较小。在酸性和中性条件下的效果比在碱性条件下的好。CAP主要在电极表面直接氧化，间接氧化也通过生成·OH和SO4·-进行。已经假设了15个中间体和2个降解途径。CAP和CAP中间体进入环境导致细菌群落和ARGs的改变，而完全降解产物对它们的影响很小。冗余分析表明，intI1是影响ARGs丰度的主要因素，放线菌和帕特斯菌是影响微生物群落中ARGs含量的主要因素。
Abstract
Antibiotics accumulation in the environment has given rise to multi-drug resistant 'superbugs' and antibiotics resistence genes (ARGs). Chloramphenicol (CAP), a kind of widely used antibiotics, was chosen as the model compound to investigate its degradation during electrochemical treatment process. The prepared Ti/PbO2–La electrodes had a denser surface and a more complete PbO2 crystal structure than Ti/PbO2 electrode. The doping of La increased the onset potential and the overpotential, increased the current value of the oxidation peak and the reduction peak, reduced the impedance, and increased the lifetime. The reactions CAP degradation and TOC removal on Ti/PbO2–La electrode was both primary kinetic reactions. CAP degradation rate increased with current density, and TOC obtained the highest removal at current density of 25 mA cm−2. The electrolyte concentration had a small effect in the range of 0.050–0.150 mol L−1. The effects under acidic and neutral conditions were better than under alkaline conditions. CAP was mainly directly oxidized at the electrode surface and indirect oxidation also took place via generated ·OH and SO4·-. 15 intermediates and 2 degradation pathways have been postulated. The entry of CAP and CAP intermediates into the environment caused the alteration in bacterial community and ARGs, while complete degradation products had little effect on them. Redundancy analysis showed that intI1 was the dominant factor affecting ARGs, and Actinobacteria and Patescibacteria were the main factors affecting the abundances of ARGs in the microbial community.

https://www.sciencedirect.com/science/article/abs/pii/S0269749122002457