摘要
      城市固体废物填埋场是抗生素和抗生素耐药性的最重要来源之一。垃圾填埋系统中抗生素和抗生素抗性基因的检测已经取得了相当大的进展。然而，对ARGs的环境特征、传播机制、影响因素和健康风险仍缺乏全面和可预测的了解。目前的综述从抗生素和抗生素耐药性的全球观点开始，然后为未来的研究方向提供建议。综述包括以下方向：（1）长期抗生素耐药性的环境行为；（2） 多药耐药基因分布与动力学；（3） 抗生素耐药性与宿主之间的联系，尤其是宿主与病原体之间的联系；（4） ARGs和微塑料作为新出现的污染物的共同进化；（5） 抗生素耐药性风险评估；以及（6）朝向垃圾填埋系统中的一个健康框架。
Abstract
Municipal solid waste landfill serves as one of the most important sources of antibiotics and antibiotic resistance. Considerable progress has been made in the detection of antibiotics and antibiotic resistant genes (ARGs) in landfills system. However, a comprehensive and predictive understanding of the environmental characteristics, transmission mechanisms, impact factors, and health risks of ARGs are still lacking. The current review begins with a global view on the status of antibiotics and antibiotic resistance, and then provides recommendations for future research directions. The review encompasses the following directions: (1) long-term antibiotic resistance environmental behavior; (2) multidrug resistance gene distribution and dynamics; (3) link between antibiotic resistance and the host, especially the host–pathogen link; (4) coevolution of ARGs and microplastics as emerging contaminants; (5) antibiotic resistance risk assessment; and (6) toward a one health framework in the landfill system.

https://www.sciencedirect.com/science/article/pii/S2468584422000964