摘要
      随着饮用水处理厂中抗生素和抗生素耐药性基因（ARGs）的广泛检测，饮用水的安全性越来越受到关注。因此，抗生素和ARGs在饮用水系统中的分布和去除需要进一步研究。在本研究中，通过高压液相色谱-串联质谱法和实时定量聚合酶链反应分析，对两种饮用水植物中的9种典型抗生素、9种ARGs和1种整合素进行了研究。磺酰胺类抗生素是两个饮用水处理厂（WP-A和WP-B）的主要抗生素。深度水处理对总抗生素浓度的去除效果显著高于常规处理。Sul基因是两种植物原水中的显性基因。经过不同的处理单元后，WP-A和WP-B中的成品水分别表现出54.06基因/mL和67.9基因/mL的Sul基因浓度。在常规处理过程中，在絮凝单元之前增加砂滤单元可以提高抗生素和ARGs的去除效率。在深度处理过程中，利用O3的强氧化作用的后臭氧氧化装置可以有效去除抗生素和ARGs。尽管活性炭单元可以有效去除抗生素，但ARGs的去除效果较差。氯化对抗生素的去除效果不佳，但可以有效去除ARGs。这项研究可以为了解抗生素和ARGs在饮用水系统中的命运提供基础。
Abstract
With the extensive detection of antibiotics and antibiotic resistance genes (ARGs) in drinking water treatment plants, the safety of drinking water has received increased attention. Therefore, the distribution and removal of antibiotics and ARGs in drinking water systems require further investigation. In this study, nine typical antibiotics, nine ARGs, and one integron in two drinking water plants were investigated by high pressure liquid chromatography with tandem mass spectrometry and real-time quantitative polymerase chain reaction analyses. Sulfonamides were the dominant antibiotic in the two drinking water treatment plants (WP-A and WP-B). The removal effect of advanced water treatment on total antibiotic concentration was significantly higher than that of conventional treatment. Sul gene was the dominant gene in the raw water of the two plants. After undergoing different treatment units, the finished water in WP-A and WP-B exhibited Sul gene concentrations of 54.06 genes/mL and 67.9 genes/mL, respectively. In the conventional treatment process, adding a sand filtration unit before the flocculation unit can improve the removal efficiency of antibiotics and ARGs. In the advanced treatment process, the post ozonization unit using the strong oxidation of O3 could effectively remove antibiotics and ARGs. Although the activated carbon unit can effectively remove antibiotics, the removal effect of ARGs is poor. Chlorination has a poor effect on the removal of antibiotics, but it can effectively remove ARGs. This study can provide a basis for understanding the fate of antibiotics and ARGs in drinking water systems.

https://www.sciencedirect.com/science/article/abs/pii/S2214714422006614