摘要
      来源于致病性和兼性致病菌的抗生素抗性基因（ARGs）的常见对水生环境构成了高风险。传统废水处理过程中ARGs的去除率低，环境细菌和人类病原体之间的耐药性基因水平传播，使抗生素耐药性演变成为一个复杂的全球健康问题。消毒后细菌再生的现象引起了人们对处理过的水的长期安全性的一些担忧。尽管活的抗生素抗性细菌（ARB）失活，但转移完整和释放的含有ARG的DNA的可能性仍然存在。朝着这个方向迈出的一步是应用新型消毒方法来详细解决这个问题，例如基于光的高级氧化，这可能会增强光与DNA直接相互作用的效果。本研究致力于全面而批判性地回顾光驱动消毒的现状。本文的主要重点是深入了解目前世界各地正在研究的不同光化学消毒方法，将ARGs去除作为传统方法的替代方法。考虑到UV/氯化、UV/H2O2、基于硫酸根的AOP、光催化工艺和光Fenton在分子水平上的作用模式、工艺的操作参数和ARGs的整体去除效率，对其进行了系统比较。深入讨论了不同的光依赖性失活途径、DBP和DOM对ARG去除的影响以及处理后潜在的细菌再生。根据所提出的修订，已经评估了从重新激活的细菌转移ARG的风险，为解决基于光的消毒技术的挑战提供了未来的研究方向。
Abstract
The common occurrence of antibiotic-resistance genes (ARGs) originating from pathogenic and facultative pathogenic bacteria pose a high risk to aquatic environments. Low removal of ARGs in conventional wastewater treatment processes and horizontal dissemination of resistance genes between environmental bacteria and human pathogens have made antibiotic resistance evolution a complex global health issue. The phenomenon of regrowth of bacteria after disinfection raised some concerns regarding the long-lasting safety of treated waters. Despite the inactivation of living antibiotic-resistant bacteria (ARB), the possibility of transferring intact and liberated DNA containing ARGs remains. A step in this direction would be to apply new types of disinfection methods addressing this issue in detail, such as light-based advanced oxidation, that potentially enhance the effect of direct light interaction with DNA. This study is devoted to comprehensively and critically review the current state-of-art for light-driven disinfection. The main focus of the article is to provide an insight into the different photochemical disinfection methods currently being studied worldwide with respect to ARGs removal as an alternative to conventional methods. The systematic comparison of UV/chlorination, UV/H2O2, sulfate radical based-AOPs, photocatalytic processes and photoFenton considering their mode of action on molecular level, operational parameters of the processes, and overall efficiency of removal of ARGs is presented. An in-depth discussion of different light-dependent inactivation pathways, influence of DBP and DOM on ARG removal and the potential bacterial regrowth after treatment is presented. Based on presented revision the risk of ARG transfer from reactivated bacteria has been evaluated, leading to a future direction for research addressing the challenges of light-based disinfection technologies.

https://www.sciencedirect.com/science/article/abs/pii/S0048969722000900