摘要
      在过去的十年里，抗生素耐药性基因加速了微生物对人类健康的威胁。填埋场作为“一个健康”系统的关键组成部分，有助于ARGs在人为废物和自然环境之间的循环中循环。在这里，我们批判性地总结了垃圾填埋场ARGs的动态，并对潜在驱动因素的当前证据提供了一个视角。与抗生素和其他环境因素相比，在垃圾填埋场的整个寿命期内，可移动的遗传元素对嵌入细菌组合的抗性组的分布影响更大。建议基于宏基因组学进行进一步研究，以探索和定量评估垃圾填埋场携带的ARGs，特别是病原体携带的ARG暴露于人类的风险情景。
Abstract
Antibiotic resistance genes (ARGs) have accelerated microbial threats to human health in the last decade. Landfills functioning as the key component in the “One Health” system facilitate the circulation of ARGs in the loop between anthropogenic waste and natural environments. Here, we critically summarized the dynamics of landfill-borne ARGs and provided a perspective on current evidence of potential drivers. Compared to the antibiotics and other environmental factors, mobile genetic elements more strongly influenced the distribution of resistome that embedded into bacterial assemblages during the whole life-span of landfills. Further studies based on metagenomics were suggested to explore and quantitatively assess the risk scenarios of landfill-borne ARGs, especially of those hosted by pathogens, exposed to human beings.

https://www.sciencedirect.com/science/article/pii/S246858442200099X