摘要

抗生素耐药性是一种普遍的全球性健康威胁。 为了对抗阻力传播，有必要考虑所有可能的来源，并理解阻力传播的途径和机制。 迫切需要最佳管理措施来阻止抗药性传播，并最大限度地延长抗生素作为宝贵资源的寿命。 在此，我们建议需要协调一致的国家和国际战略，突出三个基本组成部分：（1）监测，（2）风险评估和（3）减轻抗生素耐药性。 所有三个组件的中心是什么来监控，评估和缓解？ 我们在环境框架内解决这个问题，并从推动抗药性传播的基本微生物生态过程中吸取教训。

Antibiotic resistance is a pervasive global health threat. To combat the spread of resistance, it is necessary to consider all possible sources and understand the pathways and mechanisms by which resistance disseminates. Best management practices are urgently needed to provide barriers to the spread of resistance and maximize the lifespan of antibiotics as a precious resource. Herein we advise upon the need for coordinated national and international strategies, highlighting three essential components: (1) Monitoring, (2) Risk Assessment, and (3) Mitigation of antibiotic resistance. Central to all three components is What exactly to monitor, assess, and mitigate? We address this question within an environmental framework, drawing from fundamental microbial ecological processes driving the spread of resistance.

https://pubs.acs.org/doi/abs/10.1021/acs.est.7b03623