摘要

中国病原体耐药性上升的速度是世界上最快的。然而，沙门氏菌血清型的抗性模式仍然未知。本研究旨在描述沙门氏菌血清型的抗性模式，并确认抗生素耐药性与血清型相关基因之间可能的关联。鉴定出5种沙门氏菌血清型，其中伤寒沙门氏菌（41.67％），肠炎沙门氏菌（20.83％）和鼠伤寒沙门氏菌（18.75％）是最常见的三种菌株。大部分沙门氏菌菌株（93.75％）对一种或多种抗微生物化合物具有抗性。多重耐药性仅在鸡的沙门氏菌中发现，而来自猪肉的分离物仅抵抗四环素。检测到11个抗性基因中的8个。八个沙门氏菌分离株可将抗性基因转移至受体菌株。这些结果表明沙门氏菌分离株对多种类型的抗生素具有抗性，并且可以通过基于动物的食物将抗性传播给人。

The rate of the rise of drug resistance among pathogens in China is the fastest in the world. However, the resistance patterns for Salmonella serovars remain unknown. This study aimed to describe the resistance patterns for Salmonellaserovars and confirm possible associations between antibiotic resistance and genes in connection to serovars. Five Salmonella serotypes were identified, with S. typhi (41.67%), S. enteritidis (20.83%) and S. typhimurium (18.75%) being the three most common strains. The majority of the Salmonella strains (93.75%) were resistant to one or more antimicrobial compounds. Multidrug resistance was only found in Salmonella from chicken, whereas isolates from pork were only resistant to tetracycline. Eight of 11 resistance genes were detected. Eight Salmonella isolates could transfer resistance genes to the recipient strain. These results indicated that the Salmonella isolates were resistant to more than one type of antibiotic, and resistance could be transmitted to humans through animal‐based foods.

https://onlinelibrary.wiley.com/doi/full/10.1111/jfs.12314